MSU Crystals Enhance TDB-Mediated Inflammatory Macrophage IL-1β Secretion

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Title

MSU Crystals Enhance TDB-Mediated Inflammatory Macrophage IL-1β Secretion

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

The tumour microenvironment predominantly consists of macrophages with phenotypes ranging from pro-inflammatory (M1-like) to anti-inflammatory (M2-like). Trehalose-6,6′-dibehenate (TDB) displays moderate anti-tumour activity and stimulates M1-like macrophages via the macrophage inducible C-type lectin (Mincle) resulting in IL-1β production. In this study, we examined if monosodium urate (MSU), a known vaccine adjuvant, can boost IL-1β production by TDB-stimulated macrophages. We investigated ...

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Format

Research paper

Research format

Scholarly text / Journal article

Date created

2025

Creator

K Wahi / Kristel Kodar / Melanie-Jane McConnell / JL Harper / Mattheus Timmer / Bridget Stocker

URL

https://figshare.com/articles/journal contribution/MSU_Crystals_Enhance_TDB-Mediated_Inflammatory...

Related subjects

Biomedical and clinical sciences / Immunology / trehalose dibehenate / monosodium urate crystals / macrophages / APC / adjuvant / M1-like / Animals / Antineoplastic Combined Chemotherapy Protocols / Glycolipids / Granulocyte-Macrophage Colony-Stimulating Factor / Humans / Interleukin-1beta / Mice / Neoplasms / Tumor Microenvironment / Uric Acid / Biomedical and Clinical Sciences / Infectious Diseases / Emerging Infectious Diseases / Cancer / Good Health and Well Being

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