Synthesis of cyclodextrin composites incorporating targeting and drug carrying capabilities : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Chemistry, Massey University, Turitea Campus, Palmerston North, New Zealand

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Title

Synthesis of cyclodextrin composites incorporating targeting and drug carrying capabilities : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Chemistry, Massey University, Turitea Campus, Palmerston North, New Zealand

Content partner

Massey University

Collection

Massey Research Online

Description

A selective, versatile, and robust methodology for the bi-functionalisation of - cyclodextrin has been developed which allows for the attachment of peptides and/or sulfonamides in varying C- and N-terminal combinations on resin using NFluorenylmethoxycarbonyl (Fmoc) Solid Phase Peptide Synthesis (SPPS). Mono-6Afluorenylmethyloxycarbonylamino- mono-6X-succinyl-b-cyclodextrin, an amino acid based bi-functionalised derivative of b-cyclodextrin, has been functionalised with the bioactive p...

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Format

Research paper

Research format

Thesis

Thesis level

Doctoral

Date created

2010

URL

http://hdl.handle.net/10179/1797

Related subjects

Cyclodextrin composites / Cancer cells / Tumour cells / Chemistry / Fields of Research::250000 Chemical Sciences::250300 Organic Chemistry::250302 Biological and medical chemistry

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