A metabolite-sensitive, thermodynamically constrained model of cardiac cross-bridge cycling: implications for force development during ischemia.

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Title

A metabolite-sensitive, thermodynamically constrained model of cardiac cross-bridge cycling: implications for force development during ischemia.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

We present a metabolically regulated model of cardiac active force generation with which we investigate the effects of ischemia on maximum force production. Our model, based on a model of cross-bridge kinetics that was developed by others, reproduces many of the observed effects of MgATP, MgADP, Pi, and H(+) on force development while retaining the force/length/Ca(2+) properties of the original model. We introduce three new parameters to account for the competitive binding of H(+) to the Ca(2...

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Format

Research paper

Research format

Journal article

Date created

2010-01-20

Creator

Tran, Kenneth / Smith, Nicolas / Loiselle, Denis / Crampin, Edmund

URL

http://hdl.handle.net/2292/7782

Related subjects

Adenosine Diphosphate / Adenosine Triphosphate / Algorithms / Animals / Computer Simulation / Guinea Pigs / Heart / Hydrogen-Ion Concentration / Ischemia / Kinetics / Models, Cardiovascular / Phosphates / Reproducibility of Results / Thermodynamics / Time Factors

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