Non-steady-state calcium handling in failing hearts from the spontaneously hypertensive rat.

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Title

Non-steady-state calcium handling in failing hearts from the spontaneously hypertensive rat.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

It is generally agreed that changes in Ca(2+) cycling are often associated with heart failure, yet the impact of these changes on a beat-to-beat basis remains unclear. Measurements of isometric force and [Ca(2+)](i) were made at 37°C in left ventricular trabeculae from failing spontaneously hypertensive rat (SHR) hearts, and their normotensive Wistar-Kyoto (WKY) controls. At 1 Hz, peak stress was reduced in SHR (14.5 ± 2.4 mN mm(-2) versus 22.5 ± 6.7 mN mm⁻² for WKY), although the Ca(2+) tran...

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Format

Research paper

Research format

Journal article

Date created

2010-11

Creator

Ward, Marie-Louise / Crossman, David / Loiselle, Denis / Cannell, MB

URL

http://hdl.handle.net/2292/7783

Related subjects

Animals / Calcium / Heart Failure / Heart Ventricles / Myocardial Contraction / Rats / Rats, Inbred SHR / Rats, Inbred WKY / Sarcolemma / Sarcoplasmic Reticulum / Sarcoplasmic Reticulum Calcium-Transporting ATPases / Sodium-Calcium Exchanger

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