Thermodynamics of the fragile X mental retardation protein RGG box interactions with G quartet forming RNA

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Title

Thermodynamics of the fragile X mental retardation protein RGG box interactions with G quartet forming RNA

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

Fragile X syndrome, the most common form of inherited mental retardation, is the result of an unstable expansion of a CGG trinucleotide repeat in the 5′ UTR of the fragile X mental retardation-1 (FMR1) gene. The abnormal hypermethylation of the expanded CGG repeats causes the transcriptional silencing of the FMR1 gene and, consequently, the loss of the fragile X mental retardation protein (FMRP). FMRP is an RNA binding protein that binds to G quartet forming RNA using its RGG box motif. In th...

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Format

Research paper

Research format

Journal article

Date created

2006-07-11

Creator

Zanotti, KJ / Lackey, PE / Evans, Genevieve / Mihailescu, MR

URL

http://hdl.handle.net/2292/7844

Related subjects

MESSENGER-RNAS / CRYSTAL-STRUCTURE / IN-VIVO / BINDING / FMRP / DOMAIN / IDENTIFICATION / POLYRIBOSOMES / PEPTIDE / GENE

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