Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?

About this item

Title

Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The specificity of a range of heterocyclic product analogues against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined. The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacter...

Read more

Format

Research paper

Research format

Journal article

Date created

2008-01-15

Creator

Mitsakos, V / Dobson, Renwick / Pearce, FG / Devenish, SR / Evans, Genevieve / Burgess, BR / Perugini, MA / Gerrard, Juliet / Hutton, CA

URL

http://hdl.handle.net/2292/7846

Related subjects

N-ACETYLNEURAMINATE LYASE / ESCHERICHIA-COLI / MECHANISM / EXPRESSION / CLONING / LYSINE

What is the copyright status of this item?

Share

See below for specifics about how you may use this item.

More Information

The University of Auckland Library has this to say about the rights status of this item:

Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0960-894X/

You can learn more about the rights status of this item at:

• https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
• http://purl.org/eprint/accessRights/RestrictedAccess

What can I do with this item?

You must always check with The University of Auckland Library to confirm the specific terms of use, but this is our understanding:

Non-infringing use

NZ Copyright law does not prevent every use of a copyright work. You should consider what you can and cannot do with a copyright work.

Share it

This item is suitable for copying and sharing with others, without further permission.

No modifying

You are not allowed to adapt or remix this item into any other works.

No commercial use

You may not use this item commercially.