Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice

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Title

Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

Early loss of CB1 receptors is a hallmark of human Huntington's disease. Data from rodent studies suggest that preservation and activation of CB1 receptors may be protective against disease progression. R6/1 transgenic mice are considered to be a model of early pathogenic changes in Huntington's disease. We have shown previously that levels of CB1 in R6/1 mice prior to the onset of motor symptoms (12 weeks of age) remain high enough to justify commencement of cannabinoid drug treatment. Eight...

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Format

Research paper

Research format

Journal article

Date created

2010-09-29

Creator

Dowie, Megan / Howard, ML / Nicholson, Louise / Faull, Richard / Hannah, AJ / Glass, Michelle

URL

http://hdl.handle.net/2292/9228

Related subjects

R6/1 / CB1 / ubiquitin / neurodegeneration / ACID AMIDE HYDROLASE / MOUSE MODEL / CB1 RECEPTOR / RAT-BRAIN / ENDOCANNABINOID LEVELS / ANANDAMIDE HYDROLYSIS / MULTIPLE-SCLEROSIS / SUBSTANTIA-NIGRA / IN-VIVO / ONSET

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Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0306-4522/

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