A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation

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Title

A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Reactivation of silenced tumor suppressor genes by 5-azacytidine (Vidaza) and its congener 5-aza-2′-deoxycytidine (decitabine) has provided an alternate approach to cancer therapy. We have shown previously that these drugs selectively and rapidly induce degradation of the maintenance DNA methyltransferase (DNMT) 1 by a proteasomal pathway. Because the toxicity of these compounds is largely due to their incorporation into DNA, it is critical to explore novel, nonnucleoside compounds that can e...

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Format

Research paper

Research format

Journal article

Date created

2009

Creator

Datta, J / Ghoshal, K / Denny, William / Gamage, Swarnalatha / Brooke, Darby / Phiasivongsa, P / Redkar, S / Jacob, ST

URL

http://hdl.handle.net/2292/9209

Related subjects

CANCER-CELL LINES / RECEPTOR-TYPE-O / HISTONE DEACETYLASE / RAT HEPATOMA / IN-VIVO / METHYLATION / INHIBITORS / 5-AZA-2'-DEOXYCYTIDINE / THERAPY / DEMETHYLATION

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Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0008-5472/

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• Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0008-5472/
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