A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis treatment.

About this item

Title

A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis treatment.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Summary Drug discovery and development, from an initial disease treatment concept to a new drug application (NDA), is a complex, lengthy and expensive process. In this review we discuss the key stages of drug discovery and early development, including target identification and validation, assay development and screening, confirmed hits to leads, lead optimization, and progressing development candidates to an investigational new drug (IND) filing. We also provide particular examples of how thi...

Read more

Format

Research paper

Research format

Journal article

Date created

2008

Creator

Showalter, HD / Denny, William

URL

http://hdl.handle.net/2292/9213

Related subjects

tuberculosis / Mycobacterium tuberculosis / drug discovery / fluoroquinolones / oxazolidinones / diarylquinolines / nitroimidazooxazoles / nitroimidazooxazines / SUBSTANCE OFLOXACIN DL8280 / IN-VITRO ACTIVITIES / MYCOBACTERIUM-TUBERCULOSIS / DNA GYRASE / PULMONARY TUBERCULOSIS / ANTITUBERCULOSIS ACTIVITY / ANTIMICROBIAL AGENTS / MURINE TUBERCULOSIS / LEAD OPTIMIZATION / ATP SYNTHASE

What is the copyright status of this item?

All Rights Reserved

This item is all rights reserved, which means you'll have to get permission from The University of Auckland Library before using it.

More Information

The University of Auckland Library has this to say about the rights status of this item:

Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1472-9792/

You can learn more about the rights status of this item at:

• Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1472-9792/
• https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
• http://purl.org/eprint/accessRights/RestrictedAccess

What can I do with this item?

You must always check with The University of Auckland Library to confirm the specific terms of use, but this is our understanding:

Non-infringing use

NZ Copyright law does not prevent every use of a copyright work. You should consider what you can and cannot do with a copyright work.

No sharing

You may not copy and/or share this item with others without further permission. This includes posting it on your blog, using it in a presentation, or any other public use.

No modifying

You are not allowed to adapt or remix this item into any other works.

No commercial use

You may not use this item commercially.