Research paper
Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors.
About this item
- Title
- Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors.
- Content partner
- The University of Auckland Library
- Collection
- ResearchSpace@Auckland
- Description
Tirapazamine (TPZ) has attractive features for targeting hypoxic cells in tumors but has limited clinical activity, in part because of poor extravascular penetration. Here, we identify improved TPZ analogues by using a spatially resolved pharmacokinetic/pharmacodynamic (SR-PKPD) model that considers tissue penetration explicitly during lead optimization.
- Format
- Research paper
- Research format
- Journal article
- Date created
- 2010-10
- Creator
- Hicks, Kevin / Siim, BG / Jaiswal, Jagdish / Pruijn, Frederik / Fraser, AM / Patel, R / Hogg, A / Liyanage, HD / Dorie, MJ / Brown, JM / Denny, William / Hay, Michael / Wilson, William
- URL
- https://hdl.handle.net/2292/9255
- Related subjects
- Algorithms / Animals / Antineoplastic Agents / Cell Hypoxia / HT29 Cells / Humans / Male / Mice / Mice, Nude / Models, Biological / Neoplasms / Oxygen / Radiation-Sensitizing Agents / Rats / Rats, Sprague-Dawley / Triazines / Xenograft Model Antitumor Assays
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- Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1078-0432/
- https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
- http://purl.org/eprint/accessRights/RestrictedAccess
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What can I do with this item?
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If you believe this item breaches our terms of use please report this item
Report this itemDigitalNZ brings together more than 30 million items from institutions so that they are easy to find and use. This information is the best information we could find on this item. This item was added on 22 April 2012, and updated 17 September 2025.
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