The role of dynamics in enzyme activity

About this item

Title

The role of dynamics in enzyme activity

Content partner

University of Waikato

Collection

ResearchCommons@Waikato

Description

Although protein function is thought to depend on flexibility, precisely how the dynamics of the molecule and its environment contribute to catalytic mechanisms is unclear. We review experimental and computational work relating to enzyme dynamics and function, including the role of solvent. The evidence suggests that fast motions on the 100 ps timescale, and any motions coupled to these, are not required for enzyme function. Proteins where the function is electron transfer, proton tunneling, ...

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Format

Research paper

Research format

Journal article

Date created

2003

Creator

Daniel, Roy M. / Dunn, Rachel V. / Finney, John L. / Smith, Jeremy C.

URL

https://hdl.handle.net/10289/4452

Related subjects

protein flexibility / enzyme stability / dynamical transition / solvation / hydration

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