Elevated glucocorticoid metabolism in placental tissue from first trimester pregnancies at increased risk of pre-eclampsia.

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Title

Elevated glucocorticoid metabolism in placental tissue from first trimester pregnancies at increased risk of pre-eclampsia.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

The local actions of glucocorticoids in the placenta can be modulated by 11β-hydroxysteroid dehydrogenase (11βHSD) enzymes, which catalyse inter-conversion of cortisol with its inert metabolite, cortisone, and are known to be expressed in the term placenta and decidua. However, the expression and activity of these enzymes have not been well characterised in the first trimester placenta. The aim of this study was to compare 11βHSD2 expression and activity in first trimester placental tissue fr...

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Format

Research paper

Research format

Journal article

Date created

2011-09

Creator

Mukherjee, S / James, Joanna / Thilaganathan, B / Whitley, GS / Michael, AE / Cartwright, JE

URL

http://hdl.handle.net/2292/9371

Related subjects

Glucocorticoid / 11 beta HSD / Pre-eclampsia / Placenta / 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2 / UTERINE ARTERY DOPPLER / TROPHOBLAST DIFFERENTIATION / HYPERTENSIVE DISORDERS / 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE / EXPRESSION / HYPOXIA / OXYGEN / CELLS / TERM

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