Brefeldin A triggers apoptosis associated with mitochondrial breach and enhances HA14-1- and anti-Fas-mediated cell killing in follicular lymphoma cells.

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Title

Brefeldin A triggers apoptosis associated with mitochondrial breach and enhances HA14-1- and anti-Fas-mediated cell killing in follicular lymphoma cells.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Follicular lymphoma (FL) remains a fatal disease of increasing worldwide incidence. Since patients with FL eventually develop resistance to conventional anticancer agents, and due to BCL-2 overexpression present with profoundly compromised execution of mitochondrial pathway of apoptosis, targeting alternative pathways of cell demise may appear therapeutically beneficial. Herein we report for the first time the effects of an ER-Golgi transport inhibitor, Brefeldin A (BFA), alone and in combina...

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Format

Research paper

Research format

Journal article

Date created

2007-12

Creator

Wlodkowic, Donald / Skommer, Joanna / Pelkonen, J

URL

http://hdl.handle.net/2292/9696

Related subjects

Antibodies, Monoclonal / Antigens, CD95 / Apoptosis / Benzopyrans / Brefeldin A / Caspases / Cell Line, Tumor / Endoplasmic Reticulum / Humans / Lymphoma, Follicular / Mitochondria / Nitriles / Oxidative Stress / Proto-Oncogene Proteins c-bcl-2

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