Multiparametric analysis of HA14-1-induced apoptosis in follicular lymphoma cells.

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Title

Multiparametric analysis of HA14-1-induced apoptosis in follicular lymphoma cells.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

The compounds aimed to directly bind and inhibit Bcl-2 and related anti-apoptotic proteins have entered the clinical or pre-clinical stage of evaluation and represent a promising new strategy to combat cancer. Having reported a pro-apoptotic function of a small molecule inhibitor of Bcl-2, HA14-1, in follicular lymphoma cell lines, we provide herein further insights into the action of this compound in our model. Employing both pharmacological inhibitor studies and multiparametric flow cytomet...

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Format

Research paper

Research format

Journal article

Date created

2006-09

Creator

Wlodkowic, Donald / Skommer, Joanna / Pelkonen, J

URL

http://hdl.handle.net/2292/9711

Related subjects

Apoptosis / Benzopyrans / Caspases / Cell Line, Tumor / Drug Screening Assays, Antitumor / Enzyme Activation / Enzyme Inhibitors / Flow Cytometry / Humans / Lymphoma, Follicular / Mitochondria / Nitriles / Proto-Oncogene Proteins c-bcl-2

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