HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells.

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Title

HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells.

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The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

The BCL-2 overexpression is a hallmark of follicular lymphoma (FL). Since patients with FL often suffer from resistant to chemotherapy refractory disease, the development of new regimens is required. Herein, we analyze for the first time the effects of a B-cell lymphoma 2 (Bcl-2) antagonist, HA14-1, alone and in combination with antineoplastic agents commonly used against follicular lymphoma, in human FL cell lines with t(14;18). All cell lines tested were sensitive to HA14-1-induced cytotoxi...

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Format

Research paper

Research format

Journal article

Date created

2006-03

Creator

Skommer, Joanna / Wlodkowic, Donald / Mättö, M / Eray, M / Pelkonen, J

URL

http://hdl.handle.net/2292/9705

Related subjects

Antineoplastic Agents / Benzopyrans / Cell Line, Tumor / DNA Fragmentation / Dexamethasone / Dose-Response Relationship, Drug / Doxorubicin / Drug Evaluation, Preclinical / Drug Synergism / Humans / Lymphoma, B-Cell / Lymphoma, Follicular / Membrane Potentials / Mitochondrial Membranes / Nitriles / Proto-Oncogene Proteins c-bcl-2 / Vincristine

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