Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death

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Title

Neuroglobin protects nerve cells from apoptosis by inhibiting the intrinsic pathway of cell death

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

In the past few years, overwhelming evidence has accrued that a high level of expression of the protein neuroglobin protects neurons in vitro, in animal models, and in humans, against cell death associated with hypoxic and amyloid insult. However, until now, the exact mechanism of neuroglobin's protective action has not been determined. Using cell biology and biochemical approaches we demonstrate that neuroglobin inhibits the intrinsic pathway of apoptosis in vitro and intervenes in activatio...

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Format

Research paper

Research format

Journal article

Date created

2010-04

Creator

Raychaudhuri, S / Skommer, Joanna / Henty, Kristen / Birch, Nigel / Brittain, Tom

URL

http://hdl.handle.net/2292/12010

Related subjects

Systems biology / Neuroglobin / Apoptosis / Mitochondria / Cytochrome c / Caspase 9 / Neurons / CYTOCHROME-C RELEASE / CASPASE ACTIVATION / OXIDATIVE STRESS / REDOX STATE / IN-VIVO / BRAIN / OXYGEN / GLOBIN / INJURY / MODEL

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