Changes in elastic fibres in the small airways and alveoli in COPD

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Title

Changes in elastic fibres in the small airways and alveoli in COPD

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The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Small airways are the major site of airflow obstruction in chronic obstructive pulmonary disease (COPD). This is attributed to loss of elastin in alveoli and fibrosis in small airways. In the present study, it was hypothesised that changes to elastic fibres in alveoli might be paralleled by a similar reduction in elastic fibres in small airways. Tissue blocks from patients who had lobectomy for bronchial carcinoma were studied. Patients were classified as COPD (forced expiratory volume in one...

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Format

Research paper

Research format

Journal article

Date created

2008

Creator

Black, Peter / Ching, Pamela / Beaumont, Brent / Ranasinghe, Himani / Taylor, G / Merrilees, Mervyn

URL

http://hdl.handle.net/2292/13178

Related subjects

chronic obstructive pulmonary disease / elastin / emphysema / histology / small airways / OBSTRUCTIVE PULMONARY-DISEASE / EMPHYSEMATOUS LUNGS / CONNECTIVE-TISSUE / COLLAGEN / SMOKERS / RECOIL / FLOW

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