Structure-based targeting of bioactive proteins into cypovirus polyhedra and application to immobilized cytokines for mammalian cell culture

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Title

Structure-based targeting of bioactive proteins into cypovirus polyhedra and application to immobilized cytokines for mammalian cell culture

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Certain insect viruses produce stable infectious micro-crystals called polyhedra which function to protect the virus after the death of infected larvae. Polyhedra form within infected cells and contain numerous virus particles embedded in a crystalline lattice of the viral protein polyhedrin. We have previously demonstrated that the N-terminal 75 amino acids of the Bombx mori cypovirus (BmCPV) turret protein (VP3) can function as a polyhedrin recognition signal leading to the incorporation of...

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Format

Research paper

Research format

Journal article

Date created

2009-09

Creator

Ijiri, H / Coulibaly, F / Nishimura, G / Nakai, D / Cooper, Yui / Takenaka, C / Ikeda, K / Nakazawa, H / Hamada, N / Kotani, E / Metcalf, Peter / Kawamata, S / Mori, H

URL

http://hdl.handle.net/2292/13197

Related subjects

Cypovirus / Polyhedra / FGF-2 / FGF-7 / EGF / Keratinocytes / FIBROBLAST-GROWTH-FACTOR / EPITHELIAL REPAIR / INDUCED APOPTOSIS / ERK ACTIVATION / FACTOR BINDING / FACTOR-ALPHA / MATRIX / HEPARIN / VIRUS / PROLIFERATION

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