About this item
- Title
- Cohesin-dependent regulation of runx genes
- Content partner
- The University of Auckland Library
- Collection
- ResearchSpace@Auckland
- Description
Runx transcription factors determine cell fate in many lineages. Maintaining balanced levels of Runx proteins is crucial, as deregulated expression leads to cancers and developmental disorders. We conducted a forward genetic screen in zebrafish for positive regulators of runx1 that yielded the cohesin subunit rad21. Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression in early embryonic development. Failure to develop differen...
- Format
- Research paper
- Research format
- Journal article
- Date created
- 2006
- Creator
- Horsfield, Julia / Anagnostou, SH / Crosier, Kathryn / Crosier, Philip
- URL
- http://hdl.handle.net/2292/13983
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Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0950-1991/
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What can I do with this item?
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Report this itemDigitalNZ brings together more than 30 million items from institutions so that they are easy to find and use. This information is the best information we could find on this item. This item was added on 22 April 2012, and updated 12 April 2024.
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