Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish

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Title

Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish

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The University of Auckland Library

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ResearchSpace@Auckland

Description

The maternal genome greatly influences vertebrate embryogenesis before activation of zygotic transcription. Dorsoventral patterning is initiated by maternal factors 1–3 , but the molecular pathways involved are incompletely understood. In frogs and fish, localized zygotic domains are induced whereby cells either express dorsal or ventral genes 1,2 . Wnt/β-catenin signalling promotes expression of the earliest dorsal zygotic genes 4 . Among key zygotic ventralizing factors are the bone morphog...

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Format

Research paper

Research format

Journal article

Date created

2008

Creator

Flores, Maria / Lam, Enid / Crosier, Kathryn / Crosier, Philip

URL

http://hdl.handle.net/2292/13988

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