Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells

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Title

Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Blood cells of an adult vertebrate are continuously generated by hematopoietic stem cells (HSCs) that originate during embryonic life within the aorta-gonad-mesonephros region. There is now compelling in vivo evidence that HSCs are generated from aortic endothelial cells and that this process is critically regulated by the transcription factor Runx1. By time-lapse microscopy of Runx1-enhanced green fluorescent protein transgenic zebrafish embryos, we were able to capture a subset of cells wit...

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Format

Research paper

Research format

Journal article

Date created

2010-08-12

Creator

Lam, EYN / Hall, Christopher / Crosier, Philip / Crosier, Kathryn / Flores, MV

URL

http://hdl.handle.net/2292/15205

Related subjects

Science & Technology / Life Sciences & Biomedicine / Hematology / HEMATOPOIETIC STEM-CELLS / ZEBRAFISH DEVELOPMENT / TRANSGENIC ZEBRAFISH / TRANSITION / PRECURSOR / ONTOGENY / GENES

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