Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages

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Title

Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineages

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Description

The immune response of a host to an invading pathogen is dependent on the capacity of its immune cell compartment to recognize highly conserved pathogen components using an ancient class of pattern recognition receptors known as Toll-like receptors (TLRs). Initiation of TLR-mediated signaling results in the induction of proinflammatory cytokines that help govern the scale and duration of any ensuing response. Specificity for TLR signaling is, in part, a result of the differential recruitment ...

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Format

Research paper

Research format

Journal article

Date created

2009

Creator

Hall, Christopher / Flores, Maria / Chien, An-Tzu / Davidson, Alan / Crosier, Kathryn / Crosier, Philip

URL

http://hdl.handle.net/2292/17898

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