A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

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Title

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Protein kinase D (PKD) family members are increasingly implicated in multiple normal and abnormal biological functions, including signaling pathways that promote mitogenesis in pancreatic cancer. However, nothing is known about the effects of targeting PKD in pancreatic cancer. Our PKD inhibitor discovery program identified CRT0066101 as a specific inhibitor of all PKD isoforms. The aim of our study was to determine the effects of CRT0066101 in pancreatic cancer. Initially, we showed that aut...

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Format

Research paper

Research format

Journal article

Date created

2010-05

Creator

Harikumar, KB / Kunnumakkara, AB / Ochi, N / Tong, Z / Deorukhkar, A / Sung, B / Kelland, L / Jamieson, Stephen / Sutherland, R / Raynham, T / Charles, M / Bagherzadeh, A / Foxton, C / Boakes, A / Farooq, M / Maru, D / Diagaradjane, P / Matsuo, Y / Sinnett-Smith, J / Gelovani, J / Krishnan, S / Aggarwal, BB / Rozengurt, E / Ireson, CR / Guha, S

URL

http://hdl.handle.net/2292/18954

Related subjects

*Carcinoma,Pancreatic Ductal/pa [Pathology] / *Cell Proliferation/de [Drug Effects] / *Pancreatic Neoplasms/pa [Pathology] / *Protein Kinase C/ai [Antagonists & Inhibitors] / *Protein Kinase Inhibitors/pd [Pharmacology] / a / Abnormal / ACTIVATION / Administration / Administration,Oral / Animals / Antineoplastic Agents/ad [Administration & Dosage] / Antineoplastic Agents/ch [Chemistry] / Antineoplastic Agents/pd [Pharmacology] / Antineoplastic Agents/tu [Therapeutic Use] / APOPTOSIS / Apoptosis/de [Drug Effects] / ARE / as / Biological / Bromodeoxyuridine / Cancer / Cancer Cell / Cancer Growth / Carcinoma,Pancreatic Ductal/dt [Drug Therapy] / CELL / CELL LINE / Cell Line,Tumor / CELL-LINE / CELL-LINES / CELLS / CONCENTRATION / CYCLIN / Cyclin D1 / D / DISCOVERY / effects / Experimental / EXPRESSION / Family / GROWTH / Humans / in / in vitro / in vivo / IN-VIVO / INDEX / Inhibitor / KINASE / LINES / Male / MICE / Mice,Nude / MODEL / Molecular Weight / Multiple / Oral / P / Pancreatic / pancreatic cancer / Pancreatic Neoplasms/dt [Drug Therapy] / PATHWAY / Phosphorylation / PROGRAM / proliferation / PROTEIN / Protein Kinase Inhibitors/ad [Administration & Dosage] / Protein Kinase Inhibitors/ch [Chemistry] / Protein Kinase Inhibitors/tu [Therapeutic Use] / PROTEIN-KINASE / Proteins / Pyrimidines/pd [Pharmacology] / Pyrimidines/tu [Therapeutic Use] / Targeting / ther / THERAPEUTICS / Time / TUMOR / Tumor Growth / XENOGRAFT / Xenograft Model Antitumor Assays

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