Self-Assembly of Ternary Insulin-Polyethylenimine (PEI)-DNA Nanoparticles for Enhanced Gene Delivery and Expression in Alveolar Epithelial Cells

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Title

Self-Assembly of Ternary Insulin-Polyethylenimine (PEI)-DNA Nanoparticles for Enhanced Gene Delivery and Expression in Alveolar Epithelial Cells

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

Enhancing gene delivery and expression in alveolar epithelial cells could offer the opportunity for the treatment of acquired and inherited lung diseases. Here, we show that particle adsorption of human insulin (INS) is capable of increasing plasmid DNA (pDNA) delivery from polyethylenimine (PEI) nanoparticles specifically in alveolar epithelial cells. INS receptors were predominantly detected on alveolar but not on bronchial epithelial cells. INS was adsorbed on the surface of PEI gene vecto...

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Format

Research paper

Research format

Journal article

Date created

2009-10

Creator

Elfinger, M / Pfeifer, C / Uezguen, S / Golas, MM / Sander, B / Maucksch, Christof / Stark, H / Aneja, MK / Rudolph, C

URL

http://hdl.handle.net/2292/10882

Related subjects

ELECTRON MICROSCOPY / IN-VIVO / OLIGONUCLEOTIDE / TRANSLOCATION / RECEPTORS / THERAPY / NUCLEI / VECTOR / MICE

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