The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes

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Title

The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes

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The University of Auckland Library

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ResearchSpace@Auckland

Description

5,6-Di-methylxanthenone-4-acetic acid (DMXAA) is a small molecule in the flavanoid class that has antitumor activity. Although classified as a ‘‘vascular disrupting agent,’’ we have recently conducted studies showing that DMXAA has remarkable efficacy in a range of tumors, working primarily as an immune modulator that activates tumor-associated macrophages and induces a subsequent CD8+ T-cell–mediated response. To more completely analyze the effect of DMXAA on CD8+ T-cell generation, we treat...

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Format

Research paper

Research format

Journal article

Date created

2007-07-15

Creator

Wallace, A / LaRosa, DF / Kapoor, V / Sun, J / Cheng, GJ / Jassar, A / Blouin, A / Ching, Lai-Ming / Albelda, SM

URL

http://hdl.handle.net/2292/11571

Related subjects

5,6-DIMETHYLXANTHENONE-4-ACETIC ACID DMXAA / FLAVONE ACETIC-ACID / KAPPA-B ACTIVATION / ANTIVASCULAR AGENT / IMMUNE-RESPONSE / DANGER SIGNALS / CANCER / INDUCTION / TUMORS / IMMUNOTHERAPY

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