Signal Transducer and Activator of Transcription (STAT)-5A and STAT5B Differentially Regulate Human Mammary Carcinoma Cell Behavior

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Title

Signal Transducer and Activator of Transcription (STAT)-5A and STAT5B Differentially Regulate Human Mammary Carcinoma Cell Behavior

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

Increased activation of signal transducer and activator of transcription (STAT)-5 has been reported in various malignancies including mammary carcinoma. However, it is only recently that potentially distinct roles of STAT5A and STAT5B in neoplasia have begun to emerge. Herein we systematically delineate the functions of STAT5A and STAT5B in human mammary carcinoma cell lines MCF-7 and T47D. Forced expression of constitutively active (CA) STAT5A enhanced both survival and anchor-age-independen...

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Format

Research paper

Research format

Journal article

Date created

2010-01

Creator

Tang, Jianzhong / Zuo, ZH / Kong, XJ / Steiner, Michael / Yin, ZN / Perry, Johanna / Zhu, T / Liu, Dongxu / Lobie, Peter

URL

http://hdl.handle.net/2292/12656

Related subjects

HUMAN GROWTH-HORMONE / INVASIVE BREAST-CANCER / E-CADHERIN / ALPHA-CATENIN / EPITHELIAL-CELL / IN-VIVO / MESENCHYMAL TRANSITION / INTESTINAL METAPLASIA / PHENOTYPIC CONVERSION / CDX2 EXPRESSION

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