Evaluation of Fluorescence Resonance Energy Transfer approaches as a tool to quantify the stability of antisense oligodeoxynucleotides

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Title

Evaluation of Fluorescence Resonance Energy Transfer approaches as a tool to quantify the stability of antisense oligodeoxynucleotides

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Antisense oligodeoxynucleotides (AsODN) are rapidly degraded by nucleases in biological fluids which compromises their efficacy as therapeutic agents. This study evaluated two Fluorescence Resonance Energy Transfer (FRET) approaches, Acceptor Photobleaching and Sensitized Emission, in terms of their suitability for quantification of oligonucleotide stability in various colloidal carrier systems in vitro. The influence of the formulations' pH and viscosity on the validity of the two approaches...

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Format

Research paper

Research format

Journal article

Date created

2012

Creator

Rupenthal, Ilva / Green, CR / Alany, Raid

URL

http://hdl.handle.net/2292/12739

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