Further Molecular Characterisation of the OVT73 Transgenic Sheep Model of Huntington's Disease Identifies Cortical Aggregates

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Title

Further Molecular Characterisation of the OVT73 Transgenic Sheep Model of Huntington's Disease Identifies Cortical Aggregates

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Background: Huntington’s disease is a neurodegenerative disorder, typically with clinical manifestations in adult years, caused by an expanded polyglutamine-coding repeat in HTT. There are no treatments that delay or prevent the onset or progression of this devastating disease. Objective and Methods: In order to study its pre-symptomatic molecular progression and provide a large mammalian model for determining natural history of the disease and for therapeutic testing, we generated and previo...

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Format

Research paper

Research format

Journal article

Date created

2013

Creator

Reid, Susanne / Patassini, S / Handley, Renee / Rudiger, SR / McLaughlan, CJ / Osmand, A / Jacobsen, Jessie / Morton, AJ / Weiss, A / Waldvogel, Henry / MacDonald, ME / Gusella, JF / Bawden, CS / Faull, Richard / Snell, Russell

URL

http://hdl.handle.net/2292/22714

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