Research paper

Further Molecular Characterisation of the OVT73 Transgenic Sheep Model of Huntington's Disease Identifies Cortical Aggregates

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Title
Further Molecular Characterisation of the OVT73 Transgenic Sheep Model of Huntington's Disease Identifies Cortical Aggregates
Content partner
The University of Auckland Library
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ResearchSpace@Auckland
Description

Background: Huntington’s disease is a neurodegenerative disorder, typically with clinical manifestations in adult years, caused by an expanded polyglutamine-coding repeat in HTT. There are no treatments that delay or prevent the onset or progression of this devastating disease. Objective and Methods: In order to study its pre-symptomatic molecular progression and provide a large mammalian model for determining natural history of the disease and for therapeutic testing, we generated and previo...

Format
Research paper
Research format
Journal article
Date created
2013
Creator
Reid, Susanne / Patassini, S / Handley, Renee / Rudiger, SR / McLaughlan, CJ / Osmand, A / Jacobsen, Jessie / Morton, AJ / Weiss, A / Waldvogel, Henry / MacDonald, ME / Gusella, JF / Bawden, CS / Faull, Richard / Snell, Russell
URL
http://hdl.handle.net/2292/22714

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