Nucleotide-binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand caucasian population: a case-control study

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Title

Nucleotide-binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand caucasian population: a case-control study

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Description

Abstract Background The nucleotide-binding oligomerization domain containing 1 (NOD1) gene encodes a pattern recognition receptor that senses pathogens, leading to downstream responses characteristic of innate immunity. We investigated the role of NOD1 single nucleotide polymorphisms (SNPs) on IBD risk in a New Zealand Caucasian population, and studied Nod1 expression in response to bacterial invasion in the Caco2 cell line. Findings DNA samples from 388 Crohn's disease (CD), 405 ulcerative c...

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Format

Research paper

Date created

2009-03-01

Creator

Barclay Murray L / Philpott Martin / Han Dug / Ferguson Lynnette R / Huebner Claudia / Gearry Richard B / McCulloch Alan / Demmers Pieter S / Browning Brian L

Contributing partner

BMC Research Notes

URL

http://www.biomedcentral.com/1756-0500/2/52

Related subjects

Medicine / Biology (General)

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