Developing a novel rabbit model of atherosclerotic plaque rupture and thrombosis by cold-induced endothelial injury

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Title

Developing a novel rabbit model of atherosclerotic plaque rupture and thrombosis by cold-induced endothelial injury

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Directory of Open Access Journals

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Directory of Open Access Journals

Description

Abstract Background It is widely believed that atherosclerotic plaque rupture and subsequent thrombosis leads to acute coronary events and stroke. However, study of the mechanism and treatment of human plaque rupture is hampered by lack of a suitable animal model. Our aim was to develop a novel animal model of atherosclerotic plaque rupture to facilitate the study of human plaque disruption and thrombosis. Methods 28 healthy male New Zealand white rabbits were randomly divided into two groups...

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Format

Research paper

Date created

2009-04-01

Creator

Jiang Zhi-Xin / Zhang Qing-Hua / Fang Shun-Miao

Contributing partner

Journal of Biomedical Science

URL

http://www.jbiomedsci.com/content/16/1/39

Related subjects

Medicine

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