ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO

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Title

ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO

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Directory of Open Access Journals

Description

Abstract Background Given the expanding scope of extracorporeal membrane oxygenation (ECMO) and its variable impact on drug pharmacokinetics as observed in neonatal studies, it is imperative that the effects of the device on the drugs commonly prescribed in the intensive care unit (ICU) are further investigated. Currently, there are no data to confirm the appropriateness of standard drug dosing in adult patients on ECMO. Ineffective drug regimens in these critically ill patients can seriously...

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Format

Research paper

Date created

2012-11-01

Creator

Shekar Kiran / Roberts Jason A / Welch Susan / Buscher Hergen / Rudham Sam / Burrows Fay / Ghassabian Sussan / Wallis Steven C / Levkovich Bianca / Pellegrino Vin / McGuinness Shay / Parke Rachael / Gilder Eileen / Barnett Adrian G / Walsham James / Mullany Daniel V / Fung Yoke L / Smith Maree T / Fraser John F

Contributing partner

BMC Anesthesiology

URL

http://www.biomedcentral.com/1471-2253/12/29

Related subjects

ECMO / Pharmacokinetics / Pharmacodynamics / Antibiotics / Sedatives / Analgesics / Therapeutic failure / Drug toxicity / Anesthesiology

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