Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease

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Title

Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease

Content partner

Directory of Open Access Journals

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Directory of Open Access Journals

Description

Abstract High levels of serum cholesterol and disruptions of the blood brain barrier (BBB) have all been implicated as underlying mechanisms in the pathogenesis of Alzheimer's disease. Results from studies conducted in animals and humans suggest that caffeine might be protective against Alzheimer's disease but by poorly understood mechanisms. Using rabbits fed a cholesterol-enriched diet, we tested our hypothesis that chronic ingestion of caffeine protects against high cholesterol diet-induce...

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Format

Research paper

Date created

2008-04-01

Creator

Ghribi Othman / Wagener John F / Gawryluk Jeremy W / Chen Xuesong / Geiger Jonathan D

Contributing partner

Journal of Neuroinflammation

URL

http://www.jneuroinflammation.com/content/5/1/12

Related subjects

Neurology / Diseases of the nervous system

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