Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

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Title

Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

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Directory of Open Access Journals

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Directory of Open Access Journals

Description

Abstract Background N-acetyl cysteine (NAC) is a glutathione precursor that has been shown to have antidepressant efficacy in a placebo-controlled trial. The current study aimed to investigate the maintenance effects of NAC following eight weeks of open-label treatment for bipolar disorder. Method The efficacy of a double blind randomized placebo controlled trial of 2 g/day NAC as adjunct maintenance treatment for bipolar disorder was examined. Participants (n = 149) had a Montgomery Asberg D...

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Format

Research paper

Date created

2012-08-01

Creator

Berk Michael / Dean Olivia M / Cotton Sue M / Gama Clarissa S / Kapczinski Flavio / Fernandes Brisa / Kohlmann Kristy / Jeavons Susan / Hewitt Karen / Moss Kirsteen / Allwang Christine / Schapkaitz Ian / Cobb Heidi / Bush Ashley I / Dodd Seetal / Malhi Gin S

Contributing partner

BMC Medicine

URL

http://www.biomedcentral.com/1741-7015/10/91

Related subjects

N-acetyl cysteine / depression / bipolar disorder / maintenance / mania / oxidative / Medicine

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