The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit

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Title

The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit

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Directory of Open Access Journals

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Directory of Open Access Journals

Description

Abstract Background High-density lipoproteins (HDL) and their main apolipoprotein, apoA-I, exhibit anti-inflammatory properties. The development of peptides that mimic HDL apolipoproteins offers a promising strategy to reduce inflammatory disease. This study aimed to compare the anti-inflammatory effects of ETC-642, an apoA-I mimetic peptide, with that of discoidal reconstituted HDL (rHDL), consisting of full-length apoA-I complexed with phosphatidylcholine, in rabbits with chronic vascular i...

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Format

Research paper

Date created

2011-11-01

Creator

Di Bartolo Belinda A / Vanags Laura Z / Tan Joanne TM / Bao Shisan / Rye Kerry-Anne / Barter Philip J / Bursill Christina A

Contributing partner

Lipids in Health and Disease

URL

http://www.lipidworld.com/content/10/1/224

Related subjects

High-density lipoproteins / apolipoproteinA-I / apolipoproteinA-I mimetic peptides / vascular inflammation / rabbits / intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) / Nutritional diseases / Deficiency diseases

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