Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits

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Title

Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits

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Directory of Open Access Journals

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Directory of Open Access Journals

Description

Abstract Background Paraplegia is the most devastating complication of thoracic or thoraco-abdominal aortic surgery. During these operations, an ischemia-reperfusion process is inevitable and the produced radical oxygen species cause severe oxidative stress for the spinal cord. In this study we examined the influence of Amifostine, a triphosphate free oxygen scavenger, on oxidative stress of spinal cord ischemia-reperfusion in rabbits. Methods Eighteen male, New Zealand white rabbits were ane...

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Format

Research paper

Date created

2009-09-01

Creator

Karanikolas Menelaos / Koletsis Efstratios N / Georgiou Christos D / Grintzalis Konstantinos / Papapostolou Ioannis / Apostolakis Efstratios / Chronidou Fany / Papathanasopoulos Panagiotis / Dougenis Dimitrios

Contributing partner

Journal of Cardiothoracic Surgery

URL

http://www.cardiothoracicsurgery.org/content/4/1/50

Related subjects

Surgery / Anesthesiology

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