Collagen V-induced nasal tolerance downregulates pulmonary collagen mRNA gene and TGF-beta expression in experimental systemic sclerosis

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Title

Collagen V-induced nasal tolerance downregulates pulmonary collagen mRNA gene and TGF-beta expression in experimental systemic sclerosis

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Directory of Open Access Journals

Description

Abstract Background The purpose of this study was to evaluate collagen deposition, mRNA collagen synthesis and TGF-beta expression in the lung tissue in an experimental model of scleroderma after collagen V-induced nasal tolerance. Methods Female New Zealand rabbits (N = 12) were immunized with 1 mg/ml of collagen V in Freund's adjuvant (IM). After 150 days, six immunized animals were tolerated by nasal administration of collagen V (25 μg/day) (IM-TOL) daily for 60 days. The collagen content ...

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Format

Research paper

Date created

2010-01-01

Creator

Parra Edwin R / Katayama Maria LH / Oliveira Cristiane C / Konno Renata / dos Anjos Daniel M / Teodoro Walcy R / Velosa Ana / Capelozzi Vera L / Yoshinari Natalino H

Contributing partner

Respiratory Research

URL

http://respiratory-research.com/content/11/1/1

Related subjects

Diseases of the respiratory system

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