Polyclonal antibody cocktails generated using DNA vaccine technology protect in murine models of orthopoxvirus disease

About this item

Title

Polyclonal antibody cocktails generated using DNA vaccine technology protect in murine models of orthopoxvirus disease

Content partner

Directory of Open Access Journals

Collection

Directory of Open Access Journals

Description

Abstract Background Previously we demonstrated that DNA vaccination of nonhuman primates (NHP) with a small subset of vaccinia virus (VACV) immunogens (L1, A27, A33, B5) protects against lethal monkeypox virus challenge. The L1 and A27 components of this vaccine target the mature virion (MV) whereas A33 and B5 target the enveloped virion (EV). Results Here, we demonstrated that the antibodies produced in vaccinated NHPs were sufficient to confer protection in a murine model of lethal Orthopox...

Read more

Format

Research paper

Date created

2011-09-01

Creator

Ballantyne John / Mikolajczyk Malgorzata G / Fisher Robert W / Kapnick Senta / Zaitseva Marina / Golden Joseph W / Golding Hana / Hooper Jay W

Contributing partner

Virology Journal

URL

http://www.virologyj.com/content/8/1/441

Related subjects

Smallpox / vaccinia immunoglobulin / monoclonal antibody / passive protection / DNA vaccine / polyclonal antibody / bioluminescence / Infectious and parasitic diseases

What is the copyright status of this item?

Share, Modify, Use commercially

See below for specifics about how you may use this item.

More Information

Directory of Open Access Journals has this to say about the rights status of this item:

CC BY (All metadata for this Directory of Open Access Journals record is available under the Creative Commons Attribution-ShareAlike License (CC BY-SA).)

You can learn more about the rights status of this item at: http://www.biomedcentral.com/about/policies/license-agreement

What can I do with this item?

You must always check with Directory of Open Access Journals to confirm the specific terms of use, but this is our understanding:

Non-infringing use

NZ Copyright law does not prevent every use of a copyright work. You should consider what you can and cannot do with a copyright work.

Share it

This item is suitable for copying and sharing with others, without further permission.

Modify it

This item is suitable for modifying, remixing and building upon, without further permission.

Use it commercially

This item is suitable for commercial use, without further permission.