Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion

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Title

Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion

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Directory of Open Access Journals

Description

Abstract Objective To determine the extent of linezolid and ertapenem penetration into the empyemic fluid using a rabbit model of empyema. Methods An empyema was created via the intrapleural injection of Escherichia coli bacteria (ATCC 35218) into the pleural space of New Zealand white rabbits. After an empyema was verified by thoracocentesis, 24 hours post inoculation, linezolid (10 mg/kg) and ertapenem (60 mg/kg) were administered intravenously into 10 and 8 infected empyemic rabbits, respe...

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Format

Research paper

Date created

2010-05-01

Creator

Tsatsakis Aristidis / Tzatzarakis Manolis / Liapakis Ioannis / Ismailos Georgios / Tryfon Stavros / Saroglou Maria / Papalois Apostolos / Bouros Demosthenes

Contributing partner

Journal of Inflammation

URL

http://www.journal-inflammation.com/content/7/1/22

Related subjects

Therapeutics / Pharmacology

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