A quantitative evaluation of gross versus histologic neuroma formation in a rabbit forelimb amputation model: potential implications for the operative treatment and study of neuromas

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Title

A quantitative evaluation of gross versus histologic neuroma formation in a rabbit forelimb amputation model: potential implications for the operative treatment and study of neuromas

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Directory of Open Access Journals

Description

Abstract Background Surgical treatment of neuromas involves excision of neuromas proximally to the level of grossly "normal" fascicles; however, proximal changes at the axonal level may have both functional and therapeutic implications with regard to amputated nerves. In order to better understand the retrograde "zone of injury" that occurs after nerve transection, we investigated the gross and histologic changes in transected nerves using a rabbit forelimb amputation model. Methods Four New ...

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Format

Research paper

Date created

2011-10-01

Creator

Kuiken Todd A / Ding Xianzhong / O'Shaughnessy Kristina D / Kim Peter S / Ko Jason H / Dumanian Gregory A

Contributing partner

Journal of Brachial Plexus and Peripheral Nerve Injury

URL

http://www.jbppni.com/content/6/1/8

Related subjects

Neuroma / targeted reinnervation / axon reaction / histomorphometry / brachial plexus / Orthopedic surgery / Neurology / Diseases of the nervous system

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