Research paper

HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy

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Title
HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy
Content partner
Directory of Open Access Journals
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Directory of Open Access Journals
Description

Abstract Background HER2 and TOP2A parameters (gene status, mRNA and protein expression) have individually been associated with the outcome of patients treated with anthracyclines. The aim of this study was to comprehensively evaluate the prognostic/predictive significance of the above parameters in early, high-risk breast cancer patients treated with epirubicin-based, dose-dense sequential adjuvant chemotherapy. Methods In a series of 352 breast carcinoma tissues from patients that had been ...

Format
Research paper
Date created
2012-01-01
Creator
Fountzilas George / Valavanis Christos / Kotoula Vassiliki / Eleftheraki Anastasia G / Kalogeras Konstantine T / Tzaida Olympia / Batistatou Anna / Kronenwett Ralf / Wirtz Ralph M / Bobos Mattheos / Timotheadou Eleni / Soupos Nikolaos / Pentheroudakis George / Gogas Helen / Vlachodimitropoulos Dimitrios / Polychronidou Genovefa / Aravantinos Gerasimos / Koutras Angelos / Christodoulou Christos / Pectasides Dimitrios / Arapantoni Petroula
Contributing partner
Journal of Translational Medicine
URL
http://www.translational-medicine.com/content/10/1/10
Related subjects
HER2 / TOP2A / gene amplification / CISH / mRNA expression / early breast cancer / randomized study / anthracyclines / taxanes / Medicine

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