Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial

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Title

Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial

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Directory of Open Access Journals

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Directory of Open Access Journals

Description

Abstract Background Despite bronchiectasis being increasingly recognised as an important cause of chronic respiratory morbidity in both indigenous and non-indigenous settings globally, high quality evidence to inform management is scarce. It is assumed that antibiotics are efficacious for all bronchiectasis exacerbations, but not all practitioners agree. Inadequately treated exacerbations may risk lung function deterioration. Our study tests the hypothesis that both oral azithromycin and amox...

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Format

Research paper

Date created

2012-08-01

Creator

Chang Anne B / Grimwood Keith / Robertson Colin F / Wilson Andrew C / van Asperen Peter P / O’Grady Kerry-Ann F / Sloots Theo P / Torzillo Paul J / Bailey Emily J / McCallum Gabrielle B / Masters Ian B / Byrnes Catherine A / Chatfield Mark D / Buntain Helen M / Mackay Ian M / Morris Peter S

Contributing partner

Trials

URL

http://www.trialsjournal.com/content/13/1/156

Related subjects

Amoxicillin-clavulanic acid / Azithromycin / Bronchiectasis / Placebo / Pulmonary exacerbations / Randomised controlled trial / Medicine (General)

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