The role of 25-hydroxyvitamin D deficiency in promoting insulin resistance and inflammation in patients with Chronic Kidney Disease: a randomised controlled trial

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Title

The role of 25-hydroxyvitamin D deficiency in promoting insulin resistance and inflammation in patients with Chronic Kidney Disease: a randomised controlled trial

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Directory of Open Access Journals

Description

Abstract Background Approximately 50% of patients with stage 3 Chronic Kidney Disease are 25-hydroxyvitamin D insufficient, and this prevalence increases with falling glomerular filtration rate. Vitamin D is now recognised as having pleiotropic roles beyond bone and mineral homeostasis, with the vitamin D receptor and metabolising machinery identified in multiple tissues. Worryingly, recent observational data has highlighted an association between hypovitaminosis D and increased cardiovascula...

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Format

Research paper

Date created

2009-12-01

Creator

Johnson David W / Hawley Carmel M / Prins Johannes B / Duncan Emma / Hickman Ingrid J / Petchey William G / Barraclough Katherine / Isbel Nicole M

Contributing partner

BMC Nephrology

URL

http://www.biomedcentral.com/1471-2369/10/41

Related subjects

Diseases of the genitourinary system / Urology

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