Testing intravitreal toxicity of rapamycin in rabbit eyes Toxicidade intravítrea da rapamicina em olhos de coelhos

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Title

Testing intravitreal toxicity of rapamycin in rabbit eyes Toxicidade intravítrea da rapamicina em olhos de coelhos

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Directory of Open Access Journals

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Directory of Open Access Journals

Description

PURPOSE: To evaluate retinal toxicity of varying doses of rapamycin when injected intravitreally in rabbits. Rapamycin is a potent immunosuppressive agent with significant antitumor and antiangiogenic properties, clinically approved for prevention of organ transplant rejection. METHODS: Twelve New Zealand albino rabbits were divided into four groups. Four different doses of rapamycin were prepared in 0.1 ml: 20 µg, 50 µg, 200 µg, and 1000 µg. Each concentration was injected in one eye of thre...

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Format

Research paper

Date created

2009-02-01

Creator

Roberta Pereira de Almeida Manzano / Gholam A. Peyman / Palwasha Khan / Muhamet Kivilcim / Patricia Chevez-Barrios / Walter Takahashi

Contributing partner

Arquivos Brasileiros de Oftalmologia

URL

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492009000100004

Related subjects

Neovascularização coroidal / Sirolimo / Uveite / Receptor 1 do fator de crescimento do endotélio vascular / Coelhos / Choroidal neovascularization / Sirolimus / Uveitis / Vascular endothelial growth factor receptor-1 / Rabbits / Ophthalmology

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