Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans

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Title

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans

Content partner

University of Waikato

Collection

ResearchCommons@Waikato

Description

Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death. Here, we report that heterozygous KO mice haploinsufficient for Nbea have higher body weight due to increased adipose tissue mass. In several feeding paradigms, heterozygous KO mice consumed more food than wild-type (WT) controls, and this consumption was primaril...

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Format

Research Paper

Research format

Journal article

Date created

2012

Creator

Olszewski, Pawel K. / Rozman, Jane / Jacobsson, Josefin A. / Rathkolb, Birgit / Stromberg, Siv / Hans, Wolfgang / Klockars, Anica / Alsiö, Johan / Riserus, Ulf / Becker, Lore / Holter, Sabine / Elvert, Ralf / Ehrhardt, Nicole / Gailus-Durner, Valérie / Fuchs, Helmut / Fredriksson, Robert / Wolf, Eckhard / Klopstock, Thomas / Wurst, Wolfgang / Levine, Allen S. / Marcus, Claude / de Angelis, Martin Hrabě / Klingenspor, Martin / Schiöth, Helgi B. / Kilimann, Manfred W.

URL

https://hdl.handle.net/10289/8888

Related subjects

ioenergetics / body weight / childhood obesity / diet / energy metabolism / food / food consumption / obesity

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