Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice.

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Title

Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice.

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The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Intimal oxidation of LDL is considered an important early event in atherogenesis, and certain antioxidants are antiatherogenic. Dietary coenrichment with vitamin E (VitE) plus ubiquinone-10 (CoQ(10), which is reduced during intestinal uptake to the antioxidant ubiquinol-10, CoQ(10)H(2)) protects, whereas enrichment with VitE alone can increase oxidizability of LDL lipid against ex vivo oxidation. In the present study, we tested whether VitE plus CoQ(10) cosupplementation is more antiatherogen...

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Format

Research paper

Research format

Journal article

Date created

2001-04

Creator

Thomas, SR / Leichtweis, Steven / Pettersson, K / Croft, KD / Mori, TA / Brown, AJ / Stocker, R

URL

http://hdl.handle.net/2292/23957

Related subjects

Animals / Mice, Inbred C57BL / Mice, Knockout / Mice / Aorta / Aortic Diseases / Arteriosclerosis / Disease Models, Animal / Vitamin E / Coenzymes / Ubiquinone / Apolipoproteins E / Lipids / Dietary Fats / Antioxidants / Cholesterol, VLDL

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