Temporal Changes in the Expression of BAX and BCL-2, and the Sub-regional Vulnerability to Cellular Apoptosis after a Binge-like Ethanol Exposure in the Developing Rattus norvegicus Hippocampus

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Title

Temporal Changes in the Expression of BAX and BCL-2, and the Sub-regional Vulnerability to Cellular Apoptosis after a Binge-like Ethanol Exposure in the Developing Rattus norvegicus Hippocampus

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Exposure to ethanol in utero can result in life-long disability. Ethanol is neurotoxic, and exposure of high doses during development results in widespread cell death. A particular brain region of interest that is affected is the hippocampus, which has implications in learning and memory. The present study uses a rat model of binge-like drinking, during the third trimester-equivalent stage of neural development of humans, to investigate cell death in the hippocampus. The optical fractionator ...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Masters

Date created

2013

Creator

Smith, Caine

URL

https://hdl.handle.net/10523/4415

Related subjects

Alcohol / FAS / FASD / Ethanol / Binge-drink / Apoptosis / Hippocampus

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