Evolution Of The Unnecessary : Investigating How fMet Became Central In Bacterial Translation Initiation

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Title

Evolution Of The Unnecessary : Investigating How fMet Became Central In Bacterial Translation Initiation

Content partner

University of Canterbury Library

Collection

UC Research Repository

Description

All bacteria initiate translation using formylated methionine, yet directly after translation, the formyl-group is removed. This sequence of addition and removal appears futile, yet every sequenced bacterial genome encodes the enzymes for formylation and deformylation, suggesting this process is essential. Puzzlingly, the process is absent from both Archaea and Eukaryotes, and moreover, bacterial mutants lacking both the formylase and deformylase activities are viable, albeit with a diminishe...

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Format

Research paper

Research format

Thesis

Thesis level

Doctoral

Date created

2015

Creator

Catchpole, Ryan, Joseph

URL

http://hdl.handle.net/10092/10334

Related subjects

evolution / translation initiation / formylation / toxin-antitoxin / post-segregational killing

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Copyright Ryan Joseph Catchpole

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