The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish

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Title

The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Inflammatory bowel disease (IBD), in the form of Crohn's disease (CD) or ulcerative colitis (UC), is a debilitating chronic immune disorder of the intestine. A complex etiology resulting from dysfunctional interactions between the intestinal immune system and its microflora, influenced by host genetic susceptibility, makes disease modeling challenging. Mutations in NOD2 have the highest disease-specific risk association for CD, and a related gene, NOD1, is associated with UC. NOD1 and NOD2 en...

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Format

Research paper

Research format

Journal article

Date created

2011-11

Creator

Oehlers, SH / Flores, MV / Hall, Christopher / Swift, Simon / Crosier, Kathryn / Crosier, Philip

URL

http://hdl.handle.net/2292/25278

Related subjects

Animals / Anti-Bacterial Agents / Cloning, Molecular / Disease Resistance / Embryonic Development / Fish Diseases / Gastrointestinal Tract / Gene Expression Regulation, Developmental / Gene Knockdown Techniques / Genetic Predisposition to Disease / Humans / Inflammatory Bowel Diseases / Larva / NADPH Oxidase / Neutrophils / Nod1 Signaling Adaptor Protein / Nod2 Signaling Adaptor Protein / RNA Splicing / Salmonella enterica / Sequence Homology, Nucleic Acid / Signal Transduction / Zebrafish / Zebrafish Proteins

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