Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats

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Title

Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats

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The University of Auckland Library

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ResearchSpace@Auckland

Description

BACKGROUND: Intracellular calcium (Ca²⁺) coordinates the cardiac contraction cycle and is dysregulated in diabetic cardiomyopathy. Treatment with triethylenetetramine (TETA), a divalent-copper-selective chelator, improves cardiac structure and function in patients and rats with diabetic cardiomyopathy, but the molecular basis of this action is uncertain. Here, we used TETA to probe potential linkages between left-ventricular (LV) copper and Ca²⁺ homeostasis, and cardiac function and structure...

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Format

Research paper

Research format

Journal article

Date created

2013

Creator

Cooper, Garth / Ward, Marie-Louise / Phillips, Anthony / Zhang, Shaoping / Kennedy, J / Barry, B / Cannell, MB / Cooper, GJ

URL

http://hdl.handle.net/2292/26131

Related subjects

Animals / Calcium / Cardiotonic Agents / Chelating Agents / Copper / Diabetes Mellitus, Experimental / Diabetic Cardiomyopathies / Heart Rate / Hypertrophy, Left Ventricular / Isometric Contraction / Male / Myocardial Contraction / Myocardium / Myofibrils / Phosphorylation / Rats / Rats, Wistar / Time Factors / Trientine / Troponin I / Ventricular Function, Left / Ventricular Remodeling

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• Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.biomedcentral.com/about/license http://www.sherpa.ac.uk/romeo/issn/1475-2840/
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