Ketofol simulations for dosing in pediatric anesthesia

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Title

Ketofol simulations for dosing in pediatric anesthesia

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The University of Auckland Library

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ResearchSpace@Auckland

Description

BACKGROUND: Propofol mixed with racemic ketamine (or 'ketofol') is popular for short procedural sedation and analgesia. Use is creeping into anesthesia, yet neither the optimal combination nor infusion rate is known. The EC(50) of propofol's antiemetic effect is reported to be 0.343 mg·l(-1), while ketamine analgesia is thought to persist with concentrations above 0.2 mg·l(-1). We aimed to determine a ketofol dosing regimen for anesthesia 30-min and 1.5-h duration in a healthy child that did ...

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Format

Research paper

Research format

Journal article

Date created

2014-08

Creator

Coulter, FL / Sturge, Jacqueline / Anderson, Brian

URL

http://hdl.handle.net/2292/26466

Related subjects

anesthesia / ketamine / pediatric / pharmacodynamics / pharmacokinetics / propofol / sedation / target concentration

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